Indolizidine (−)-235B′ and related structural analogs: Discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release
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منابع مشابه
Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release.
Although several therapeutic agents are available to aid in tobacco smoking cessation, relapse rates continue to be high, warranting the development of alternative pharmacotherapies. Nicotine-evoked dopamine release from its presynaptic terminals in the central nervous system leads to reward which maintains continued tobacco use. The ability of indolizidine (-)-235B' and a sub-library of struct...
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a Intra-Cellular Therapies, Inc., New York, NY, 10032, United States Department of Pharmacology and Therapeutics, University of Florida, College of Medicine, Gainesville, FL 32610, United States Centers for Disease Control and Prevention-National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States Department of Pharmacology, University of Medicine and Dentistry of ...
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Structural simplification of N-n-alkylnicotinium analogs, antagonists at neuronal nicotinic acetylcholine receptors (nAChRs), was achieved by removal of the N-methylpyrrolidino moiety affording N-n-alkylpyridinium analogs with carbon chain lengths of C1 to C20. N-n-Alkylpyridinium analog inhibition of [H]nicotine and [H]methyllycaconitine binding to rat brain membranes assessed interaction with...
متن کاملN-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices.
Structural simplification of N-n-alkylnicotinium analogs, antagonists at neuronal nicotinic acetylcholine receptors (nAChRs), was achieved by removal of the N-methylpyrrolidino moiety affording N-n-alkylpyridinium analogs with carbon chain lengths of C1 to C20. N-n-Alkylpyridinium analog inhibition of [3H]nicotine and [3H]methyllycaconitine binding to rat brain membranes assessed interaction wi...
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ژورنال
عنوان ژورنال: European Journal of Pharmacology
سال: 2011
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2011.02.018